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Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

Vigilance (psychology)

2 papers

Ketamine effects on default mode network activity and vigilance: A randomized, placebo‐controlled crossover simultaneous fMRI/EEG study

Norman Zacharias, Francesco Musso, Felix Müller, Florian Lammers, Andreas Saleh, Markus K. London, et al.
Human Brain Mapping Summary & key facts 2019 65 citations

This randomized, double-blind, placebo-controlled crossover study gave subanesthetic S‑ketamine to 24 healthy young people while recording fMRI and EEG at rest. After ketamine, fMRI showed less connectivity in the medial prefrontal cortex and more connectivity in left and right intraparietal (parietal) areas of the default mode network. EEG showed more…

Functional Brain Connectivity Studies Neural and Behavioral Psychology Studies Treatment of Major Depression

A Two-Phase, Dose-Ranging, Placebo-Controlled Study of the Safety and Preliminary Test of Acute Effects of Oral Δ 8 -Tetrahydrocannabivarin in Healthy Participants

Erica N. Peters, Laura MacNair, Amy Harrison, Matthew T. Feldner, Graham M.L. Eglit, Shanna Babalonis, et al.
Cannabis and Cannabinoid Research Summary & key facts 2023 7 citations

This small two-phase trial tested single oral doses of the Δ8 form of THCV (placebo and 12.5, 25, 50, 100, 200 mg) in healthy adults and followed participants for up to 8 hours. Most side effects were mild, some doses showed a possible short-term improvement in a sustained-attention test, and…

Cannabis and Cannabinoid Research Suicide and Self-Harm Studies
Summaries and links are for general information and education only. They are not a substitute for reading the original publication or for professional medical, legal, or other advice. Always refer to the linked source for the full study.