Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

2 papers

Cingulate dynamics track depression recovery with deep brain stimulation

Sankaraleengam Alagapan, Ki Sueng Choi, Stephen Heisig, Patricio Riva‐Posse, Andrea Crowell, Vineet Tiruvadi, et al.
Nature Summary & key facts 2023 233 citations

Researchers tested deep brain stimulation (DBS) in a small group of people whose depression did not get better with usual treatments. They used an implanted device that both delivered stimulation to the subcallosal cingulate (a brain area linked to mood) and recorded brain electrical signals. Around 9 out of 10…

Functional Brain Connectivity Studies Neurological disorders and treatments Transcranial Magnetic Stimulation Studies

Long-Term Occupational Stress Is Associated with Regional Reductions in Brain Tissue Volumes

Eva Blix, Aleksander Perski, Hans Berglund, Ivanka Savic
PLoS ONE Summary & key facts 2013 131 citations

Several brain-imaging studies found that people with long-term work-related burnout showed differences in brain structure and function compared with matched healthy adults. In groups where participants had worked more than about 60–70 hours per week for several years, researchers reported larger amygdala size, thinner medial prefrontal cortex (mPFC) tissue, weaker…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Functional Brain Connectivity Studies Stress Responses and Cortisol
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