Frontier mental health research: psychedelics & drug studies

Psychedelic Treatments for Psychiatric Disorders: A Systematic Review and Thematic Synthesis of Patient Experiences in Qualitative Studies

Joost J. Breeksema, Alistair Niemeijer, Erwin Krediet, Eric Vermetten, Robert A. Schoevers

CNS Drugs • Summary & key facts • 2020 • 207 citations

Researchers collected and read 15 studies where patients described their own experiences with psychedelic treatments for mental disorders. These studies looked at about 180 patient accounts across different drugs and different illnesses. Even though the drugs and treatment settings were very different, many patients described similar helpful processes, such as…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies Ayahuasca Ibogaine

Psychedelic Harm Reduction and Integration: A Transtheoretical Model for Clinical Practice

Ingmar Gorman, Elizabeth M Nielson, Aja Molinar, Ksenia Cassidy, Jonathan Sabbagh

PubMed Central (PMC) • Summary & key facts • 2021 • 124 citations

Psychedelic Harm Reduction and Integration (PHRI) is a clinical model for working with people who use or are thinking about using psychedelics. It blends harm-reduction therapy with methods from psychedelic-assisted therapy, can be used in short or ongoing psychotherapy, and aims to be compassionate and non-stigmatizing rather than focused only…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies

Psychedelic-Assisted Psychotherapy—A Systematic Review of Associated Psychological Interventions

Cavarra, Mauro, Falzone, Alessandra, Ramaekers, Johannes G., et al.

www.frontiersin.org • Summary & key facts • 2022 • 122 citations

This systematic review looked at clinical studies that paired psychedelics with a structured psychotherapy. It found that psychedelic-assisted psychotherapy can give promising results across many clinical conditions when given to carefully screened people in controlled settings, but some patients relapse or do not respond. The review highlights that individual and…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies

Psychedelic Therapy’s Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective

John R. Kelly, Claire M. Gillan, Jack Prenderville, Clare Kelly, Andrew Harkin, Gerard Clarke, et al.

Frontiers in Psychiatry • Summary & key facts • 2021 • 61 citations

This paper reviews clinical and lab studies about psychedelic therapy, which means using a psychedelic drug together with psychological support. The authors say this approach looks promising for several different mental health problems that share rigid or harmful patterns of feeling, thinking, or acting — especially major depression, depression that…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies

Psychedelics: Alternative and Potential Therapeutic Options for Treating Mood and Anxiety Disorders

Henry Lowe, Ngeh J. Toyang, Blair Steele, Justin Grant, Amza Ali, Lorenzo Gordon, et al.

Molecules • Summary & key facts • 2022 • 52 citations

This paper is a review of research about psychedelic drugs and whether they could help with mood and anxiety problems. It explains that these drugs were used for thousands of years in some cultures, then were banned in the 1960s which slowed scientific study. The authors describe a new wave…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies Ayahuasca LSD

A century of research on psychedelics: A scientometric analysis on trends and knowledge maps of hallucinogens, entactogens, entheogens and dissociative drugs

Marco Solmi, Chaomei Chen, Charles Daure, Anne Buot, Michael Ljuslin, Vincent Verroust, et al.

European Neuropsychopharmacology • Summary & key facts • 2022 • 51 citations

Researchers looked at published papers about psychedelic drugs from the last century, using citation maps and other tools to see how the field changed up to March 2022. They found that research was small and mostly about safety for many decades, then grew a lot after the 1990s into a…

Forensic Toxicology and Drug Analysis Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies Ayahuasca Ketamine

The Combination of Psychedelic and Aversive Approaches in Alcoholism Treatment

Evgeny Krupitsky, A. Ya Grineko, Тимур Ниязбекович Беркалиев, Aaron Paley, U. N. Tetrov, K. A. Mushkov, et al.

Alcoholism Treatment Quarterly • Summary & key facts • 1992 • 46 citations

Abstract The "Affective Contra-Attribution" method of alcoholism treatment consists of three stages: (1) an introductory psychotherapeutic stage; (2) psychedelic treatment with ketamine utilization: and (3) therapist led group discussion of the patients' psychedelic experiences. The stages of psychedelic treatment include psychotherapeutic dialogue with the patient within the context of the…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies

The Association Between Vulnerable/Grandiose Narcissism and Emotion Regulation

Leonie Anne Kathrin Loeffler, Anna K. Huebben, Sina Radke, Ute Habel, Birgit Derntl

Frontiers in Psychology • Summary & key facts • 2020 • 39 citations

This study tested 60 healthy adults (30 women, 30 men) to see how two types of narcissism — vulnerable and grandiose — relate to emotion regulation. Researchers used questionnaires and a lab task that asked people to either feel naturally or use reappraisal (change how they think) while viewing sad…

Emotional Intelligence and Performance Personality Disorders and Psychopathology Personality Traits and Psychology

Current Perspective on the Therapeutic Preset for Substance-Assisted Psychotherapy

Sascha Thal, Stephen Bright, Jason M. Sharbanee, Tobias Wenge, Petra Skeffington

Frontiers in Psychology • Summary & key facts • 2021 • 38 citations

This paper is a broad review that looks at how therapy that uses drugs together with psychotherapy should be done. The authors collect ideas from other studies about what therapists need to know, including ethical questions and the spiritual side of some treatments. They point out that the helpful effects…

Cannabis and Cannabinoid Research Mindfulness and Compassion Interventions Psychedelics and Drug Studies

Proposition of a transdiagnostic processual approach of emotion dysregulation based on core triggers and interpersonal styles

Blay, Martin, Duarte, Miguel, Dessouli, Marie-Alix, et al.

www.frontiersin.org • Summary & key facts • 2024 • 13 citations

This paper reviews research showing that emotion dysregulation (ED) is not only part of borderline personality disorder (BPD) but also appears across other diagnoses. The authors examined evidence for ED in 8 specific disorders and propose a transdiagnostic model that describes core triggers and interpersonal styles. They say this model…

Mental Health and Psychiatry Obsessive-Compulsive Spectrum Disorders Personality Disorders and Psychopathology

Indigenous-Amazonian Traditional Medicine’s Usage of the Tobacco Plant: A Transdisciplinary Ethnopsychological Mixed-Methods Case Study

Ilana Berlowitz, Ernesto García Torres, Caroline Maake, Ursula Wolf, Chantal Martin‐Soelch

Plants • Summary & key facts • 2023 • 13 citations

Researchers reported a single case where a traditional Amazonian healer gave a weeklong, ritual treatment that included drinking a liquid made from the native tobacco plant. The patient was a 37-year-old woman with diagnosed low mood, anxiety, and attention problems plus a long-term physical health issue. The team used both…

Complementary and Alternative Medicine Studies Medicinal Plant Extracts Effects Psychedelics and Drug Studies Other

Couple Therapy With MDMA—Proposed Pathways of Action

Wagner, Anne C.

www.frontiersin.org • Summary & key facts • 2021 • 13 citations

This paper is a theoretical review that looks at how MDMA might help couples in therapy. It reviews brain and body effects of MDMA, and how those effects could change emotions, behavior, thinking, and bodily feelings between two partners. The authors list specific interpersonal areas MDMA may affect (for example,…

Memory and Neural Mechanisms Neuroendocrine regulation and behavior Psychedelics and Drug Studies