Frontier mental health research: psychedelics & drug studies

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36 papers

Mortality Rates in Patients With Anorexia Nervosa and Other Eating Disorders

Jon Arcelus, Alex J. Mitchell, Jackie Wales, Søren Nielsen
Archives of General Psychiatry Summary & key facts 2011 2,760 citations

This fact sheet reports that people with eating disorders have higher death rates than the general population. Death rates are highest for anorexia nervosa (AN). Bulimia nervosa (BN) and eating disorder not otherwise specified (EDNOS) have similar death rates. The sheet says older age at assessment was linked to higher…

Eating Disorders and Behaviors Impact of Technology on Adolescents Obsessive-Compulsive Spectrum Disorders

Risks of all-cause and suicide mortality in mental disorders: a meta-review

Edward Chesney, Guy M. Goodwin, Seena Fazel
World Psychiatry Summary & key facts 2014 2,040 citations

This study reviewed systematic reviews to measure death risks in major mental disorders. The authors screened 407 reviews and found 20 that reported mortality risks for 20 different disorders, covering over 1.7 million patients and more than a quarter of a million deaths. Every disorder showed higher all-cause death rates…

Bipolar Disorder and Treatment Mental Health Treatment and Access Suicide and Self-Harm Studies

Mindfulness-Based Stress Reduction for Stress Management in Healthy People: A Review and Meta-Analysis

Alberto Chiesa, Alessandro Serretti

MBSR is able to reduce stress levels in healthy people. However, important limitations of the included studies as well as the paucity of evidence about possible specific effects of MBSR in comparison to other nonspecific treatments underline the necessity of further research.

COVID-19 and Mental Health Mindfulness and Compassion Interventions Resilience and Mental Health

Prevalence of eating disorders over the 2000–2018 period: a systematic literature review

Marie Galmiche, Pierre Déchelotte, Grégory Lambert, Marie‐Pierre Tavolacci
American Journal of Clinical Nutrition Summary & key facts 2018 1,604 citations

This systematic review looked at studies from 2000–2018 that measured how common eating disorders are. The authors followed PRISMA rules and included 94 studies with accurate diagnoses and 27 studies with broader categories. Across the accurate-diagnosis studies, women had higher rates than men. Point prevalence estimates rose over time from…

Eating Disorders and Behaviors Obesity, Physical Activity, Diet Obsessive-Compulsive Spectrum Disorders

The effectiveness of psychodynamic psychotherapies: An update

Peter Fonagy
World Psychiatry Summary & key facts 2015 241 citations

Researchers reviewed many outcome studies and meta-analyses of psychodynamic therapy, which is a type of talking therapy that explores feelings, relationships, and past experiences. They found that psychodynamic therapy often works better than doing nothing (for example being on a waitlist, getting only usual care, or a placebo) for depression,…

Mental Health and Psychiatry Personality Disorders and Psychopathology Psychotherapy Techniques and Applications

Psychedelic Treatments for Psychiatric Disorders: A Systematic Review and Thematic Synthesis of Patient Experiences in Qualitative Studies

Joost J. Breeksema, Alistair Niemeijer, Erwin Krediet, Eric Vermetten, Robert A. Schoevers
CNS Drugs Summary & key facts 2020 207 citations

Researchers collected and read 15 studies where patients described their own experiences with psychedelic treatments for mental disorders. These studies looked at about 180 patient accounts across different drugs and different illnesses. Even though the drugs and treatment settings were very different, many patients described similar helpful processes, such as…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies Ayahuasca Ibogaine

Psychedelic-Assisted Psychotherapy—A Systematic Review of Associated Psychological Interventions

Cavarra, Mauro, Falzone, Alessandra, Ramaekers, Johannes G., et al.
www.frontiersin.org Summary & key facts 2022 122 citations

This systematic review looked at clinical studies that paired psychedelics with a structured psychotherapy. It found that psychedelic-assisted psychotherapy can give promising results across many clinical conditions when given to carefully screened people in controlled settings, but some patients relapse or do not respond. The review highlights that individual and…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies

Therapeutic effect of psilocybin in addiction: A systematic review

van der Meer, Pim B., Fuentes, Juan J., Kaptein, Ad A., et al.
www.frontiersin.org Summary & key facts 2023 111 citations

This systematic review searched for clinical trials of psilocybin for substance use problems up to September 2, 2022. The authors found four trials with 151 patients that tested psilocybin combined with psychotherapy for alcohol or tobacco use. These small trials, including one randomized placebo-controlled trial, reported reductions in heavy drinking…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies

The Influence of the COVID-19 Pandemic on Social Anxiety: A Systematic Review

Reuben Kindred, Glen Bates

This systematic review looked at 33 studies about social anxiety during the COVID-19 pandemic. The studies suggest social anxiety increased in the general population. Women and people with low incomes appeared more likely to report higher social anxiety. Other links to higher social anxiety included poor coping, weaker social support,…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes COVID-19 and Mental Health Perfectionism, Procrastination, Anxiety Studies

The acute effects of classic psychedelics on memory in humans

C. J. Healy
Psychopharmacology Summary & key facts 2021 91 citations

This 2021 review of human studies found that classic psychedelics (for example psilocybin, LSD, ayahuasca) tend to reduce performance on standard memory tests in a dose-dependent way: low doses usually showed no impairment and higher doses caused more impairment. At the same time, these drugs often made autobiographical memories feel…

Biochemical Analysis and Sensing Techniques Chemical synthesis and alkaloids Psychedelics and Drug Studies

The Therapeutic Potential of Psychedelic-assisted Therapies for Symptom Control in Patients Diagnosed With Serious Illness: A Systematic Review

Lucas Oliveira Maia, Yvan Beaussant, Ana Cláudia Mesquita Garcia

This paper looked at 20 clinical trials to see whether therapies that use psychedelic drugs together with talking therapy can help people who have serious, life‑limiting illnesses. The review found that these therapies often helped with psychological and spiritual problems like anxiety, low mood, and fear of dying. The drugs…

Chemical synthesis and alkaloids Complementary and Alternative Medicine Studies Psychedelics and Drug Studies Ketamine LSD

Neurobiological Changes Induced by Mindfulness and Meditation: A Systematic Review

Andrea Calderone, Dèsiréè Latella, Federica Impellizzeri, Paolo De Pasquale, Fausto Famà, Angelo Quartarone, et al.
Biomedicines Summary & key facts 2024 49 citations

This systematic review of research up to 2024 found that meditation and mindfulness are linked to measurable brain changes and to better emotional regulation, cognition, and stress resilience. Many studies report thicker cortex in certain areas, lower amygdala reactivity, changes in brain connectivity and neurotransmitters, and improvements in anxiety, depression,…

Mindfulness and Compassion Interventions Music Therapy and Health Sleep and related disorders
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