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8 papers
A single ibogaine treatment reduced opioid withdrawal symptoms and achieved opioid cessation or sustained reduced use in dependent individuals as measured over 12 months. Ibogaine's legal availability in New Zealand may offer improved outcomes where legislation supports treatment providers to work closely with other health professionals.
This meta-analysis combined 14 observational studies and found that anaemia was associated with higher odds of adult depression (pooled estimate 1.43; 95% CI 1.23 to 1.65). The analysis included 10,764 cases of depression from studies with average ages between 38.4 and 75.0 years. The authors reported moderate differences across studies,…
This systematic review looked for events that can trigger sudden mood episodes in people with bipolar disorder. The authors examined 108 studies published up to May 23, 2022. They found the strongest evidence that antidepressant use is linked to manic or hypomanic episodes. Other reported triggers for mania included brain…
Project Twenty21 collected real-world data from people in the UK who sought prescribed medicinal cannabis. Data at treatment start were available for 2,833 patients and 1,410 had 3-month follow-up for anxiety, chronic pain or PTSD. On average, patients reported improvements in condition-specific symptoms and in general health and quality of…
This prospective observational study followed 438 adults who were new medical‑marijuana patients in Pennsylvania. Using the SF‑36 survey, participants reported statistically significant improvements in all eight areas of health‑related quality of life from before starting medical marijuana to three months later (P < .001 for all domains). Older participants showed…
This large Australian real-world study followed 2,353 adults who were newly prescribed medicinal cannabis oil and found that patient-reported quality of life, fatigue, sleep, pain (in people with chronic pain), and mood (in people with anxiety or depression) showed statistically significant and clinically meaningful improvements that were maintained up to…
This cross-sectional study looked at 200 people aged 16–60 in rural India who had depression and iron deficiency anaemia. It found that lower haemoglobin and other red blood cell measures were linked to worse depression scores. Over half (55.5%) had severe depression, and the authors say treating anaemia alongside depression…
