Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

5 papers

Psychological Stress and the Human Immune System: A Meta-Analytic Study of 30 Years of Inquiry

Suzanne C Segerstrom, Gregory E Miller
PubMed Central (PMC) Summary & key facts 2004 3,257 citations

This paper is a meta-analysis of more than 300 studies in humans that looked at links between psychological stress and measures of the immune system. It found that very short, acute stressors (minutes) were tied to increases in some natural (innate) immune measures and decreases in some specific (adaptive) immune…

Health, psychology, and well-being Stress Responses and Cortisol Tryptophan and brain disorders

New Insights into the Pivotal Role of the Amygdala in Inflammation-Related Depression and Anxiety Disorder

Ping Hu, Ying Lü, Bing‐Xing Pan, Wenhua Zhang

This 2022 review looks at studies linking stress, inflammation, and changes in the amygdala to depression and anxiety. It says stress can trigger inflammation in the body and brain, that inflammation can change neurons and circuits in the amygdala, and that these changes are linked to depression- and anxiety-like signs…

Neuroinflammation and Neurodegeneration Mechanisms Stress Responses and Cortisol Tryptophan and brain disorders

Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study

Xie Xiao-qian, Yan Geng, Qijie Guan, Yilin Ren, Lin Guo, Qiqi Lv, et al.
Nutrients Summary & key facts 2021 50 citations

Researchers had 13 healthy adults take Hericium erinaceus powder every day for seven days. They tested blood with routine blood and serum chemistry tests and checked gut bacteria using 16S rRNA gene sequencing. After the week, the gut bacterial community showed higher within-sample diversity and higher levels of several bacteria…

Fungal Biology and Applications Ginseng Biological Effects and Applications Gut microbiota and health

Modified Cortisol Circadian Rhythm: The Hidden Toll of Night-Shift Work

Aikaterini Andreadi, Stella Andreadi, Federica Todaro, Lorenzo Ippoliti, Alfonso Bellia, Andrea Magrini, et al.

This 2025 narrative review explains that cortisol normally peaks in the early morning and falls to its lowest levels in the early night. Night-shift work often shifts or flattens that pattern, causing a blunted or delayed morning peak and a less steep decline through the day. The authors link this…

Circadian rhythm and melatonin Climate Change and Health Impacts Stress Responses and Cortisol

Association between latent toxoplasmosis and bipolar disorder: a case-control seroprevalence study

Abdol Sattar Pagheh, Ali Talebian, Tooran Nayeri, Ali Akbar Esmaeili, Fatemeh Rezaei, Eisa Nazar, et al.
BMC Infectious Diseases Summary & key facts 2025 3 citations

Researchers tested blood from 115 people with bipolar disorder and 115 people without it for past infection with the parasite Toxoplasma gondii. They found past infection (IgG antibodies) in 24.3% of the bipolar group versus 8.7% of the control group. After accounting for other measured factors, having IgG antibodies was…

Cytomegalovirus and herpesvirus research Herpesvirus Infections and Treatments Toxoplasma gondii Research Studies
Summaries and links are for general information and education only. They are not a substitute for reading the original publication or for professional medical, legal, or other advice. Always refer to the linked source for the full study.