Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

10 papers

The World Health Organization Adult ADHD Self-Report Scale (ASRS): a short screening scale for use in the general population

Ronald C. Kessler, Lenard A. Adler, Minnie Ames, Olga Demler, Stephen V. Faraone, Eva Hiripi, et al.
PubMed Summary & key facts 2005 3,245 citations

The WHO Adult ADHD Self-Report Scale (ASRS) has 18 questions about recent ADHD symptoms, and a shorter six-question screener was tested against blind clinical diagnoses in 154 people from the US National Comorbidity Survey Replication. Each ASRS item was linked to the clinical rating, but agreement varied a lot across…

Attention Deficit Hyperactivity Disorder Functional Brain Connectivity Studies Neural and Behavioral Psychology Studies

Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial

Jennifer L. Phillips, Sandhaya Norris, Jeanne Talbot, Meagan Birmingham, Taylor Hatchard, Abigail Ortiz, et al.
American Journal of Psychiatry Summary & key facts 2019 396 citations

Repeated ketamine infusions have cumulative and sustained antidepressant effects. Reductions in depressive symptoms were maintained among responders through once-weekly infusions. These findings provide novel data on efficacious administration strategies for ketamine in patients with treatment-resistant depression. Future studies should further expand on optimizing administration to better translate the use of…

Mental Health Research Topics Treatment of Major Depression Tryptophan and brain disorders

A meta-analysis of the prevalence of attention deficit hyperactivity disorder in incarcerated populations

Susan Young, Donald Moss, Ottilie Sedgwick, Moshe Fridman, P. Hodgkins
Psychological Medicine Summary & key facts 2014 277 citations

The authors combined results from 42 studies of people in prison to estimate how common ADHD is in those groups. Using formal diagnostic interviews, the overall ADHD rate was about 25.5%. Reported rates were higher when studies used screening tools or when adults recalled childhood ADHD. The review found much…

Attention Deficit Hyperactivity Disorder Bipolar Disorder and Treatment Child and Adolescent Psychosocial and Emotional Development

Long-term outcomes of repeated ketamine infusions in patients with unipolar and bipolar depression: A naturalistic follow-up study

Weicheng Li, Yanling Zhou, Weijian Liu, Chengyu Wang, Xiaofeng Lan, Zhipei Zhang, et al.
Journal of Affective Disorders Summary & key facts 2021 13 citations

Researchers followed 108 people with unipolar or bipolar depression who had repeated ketamine infusions (three times weekly over 12 days) and then were observed for 9 months. Depression symptoms and overall function were measured with the PHQ‑9 and the GAF. Seventy‑one people (65.7%) completed the full 9‑month follow‑up. At month…

Mental Health Research Topics Treatment of Major Depression Tryptophan and brain disorders

Exploring the healing power of singing bowls: An overview of key findings and potential benefits

Rajmohan Seetharaman, Sanika Avhad, Jitesh R. Rane
EXPLORE Summary & key facts 2023 12 citations

Singing bowl sound meditation is an old Tibetan and Buddhist practice. This review of studies found short-term calming effects: lower negative mood, higher positive mood, and some small improvements in blood pressure, heart rate, and breathing in some studies. The authors say the reasons are unclear (possible changes in brain…

Biofield Effects and Biophysics Music Therapy and Health Paranormal Experiences and Beliefs

Four Weeks of Hericium erinaceus Supplementation Does Not Impact Markers of Metabolic Flexibility or Cognition

Corey D. Grozier, Victor A Alves, Lauren G. Killen, Jeffrey D. Simpson, Eric K. O’Neal, Hunter S. Waldman

Researchers tested whether taking 10 g per day of Hericium erinaceus (Lion's Mane mushroom) for four weeks changes how the body uses fuel during exercise or affects thinking in a college-age group. In a single-blind, placebo-controlled trial, 24 participants ate muffins with either the mushroom or a placebo and completed…

Exercise and Physiological Responses Fungal Biology and Applications Muscle metabolism and nutrition

Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial

Jennifer L. Phillips, Sandhaya Norris, Jeanne Talbot, Meagan Birmingham, Taylor Hatchard, Abigail Ortiz, et al.

(Reprinted with permission from The American Journal of Psychiatry 2019; 176:401-409).

Mental Health Research Topics Treatment of Major Depression Tryptophan and brain disorders

The relationship between family support system with maternal postpartum rage

Miftahul Fikri, Neviyarni Neviyarni, Afdal Afdal

This cross-sectional study surveyed 121 young mothers in West Sumatra who had children aged 1 to 24 months. The researchers used the Edinburgh Postnatal Depression Scale (EPDS) and a social support scale. They found first-time mothers had higher postpartum rage than mothers with a second or third child. The paper…

Global Socioeconomic and Political Dynamics Maternal Mental Health During Pregnancy and Postpartum

Prevalence of attention deficit hyperactivity disorder/hyperkinetic disorder of pediatric and adult populations in clinical settings: a systematic review, meta-analysis and meta-regression

S.C. Johnson, Eric Lim, Peter Jacoby, Stephen V. Faraone, Benjamin Minche Su, Marco Solmi, et al.
Molecular Psychiatry Summary & key facts 2025 2 citations

This systematic review and meta-analysis combined 311 clinical studies (653,558 children and 43,311 adults) up to August 1, 2023. It found that ADHD/hyperkinetic disorder occurred in 32.4% (95% CI 31–34%) of pediatric patients and 21.4% (95% CI 20–23%) of adult patients seen in clinical settings — about 8–9 times higher…

Attention Deficit Hyperactivity Disorder Bipolar Disorder and Treatment

Associations Between Physical Activity, Sedentary Behaviour, Sleep Quality, and Anxiety Among Healthy Pain-Free Adults in Saudi Arabia: An Online Cross-Sectional Survey

Mansour Abdullah Alshehri, Areej Ali Alzylai, Joree Abdulrahman Alshehri, Lana Zaid Alsharif, Wafa Saleem Almalki, Hammad Alhasan, et al.
Sports Summary & key facts 2025 0 citations

This online study surveyed 185 healthy, pain-free adults in Saudi Arabia between December 2024 and April 2025 using validated Arabic questionnaires for physical activity, sleep quality, and anxiety. On average participants reported 1730.02 MET·min/week of physical activity and 6.77 hours/day of sedentary time. The researchers found no significant links between…

Behavioral Health and Interventions Physical Activity and Health Sleep and related disorders
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