Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

3 papers

Effect of Internet vs Face-to-Face Cognitive Behavior Therapy for Health Anxiety: A Randomized Noninferiority Clinical Trial

Erland Axelsson, Erik Andersson, Brjánn Ljótsson, Daniel Björkander, Maria Hedman-Lagerlöf, Erik Hedman-Lagerlöf
PubMed Central (PMC) Summary & key facts 2020 116 citations

This randomized noninferiority clinical trial examines the effect of internet-delivered vs face-to-face cognitive behavior therapy especially in light of resources, access, and cost.

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Digital Mental Health Interventions Psychosomatic Disorders and Their Treatments

Psychotherapies for Generalized Anxiety Disorder in Adults: A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials

Davide Papola, Clara Miguel, Mariacristina Mazzaglia, Pamela Franco, Federico Tedeschi, Sara A Romero, et al.
PubMed Central (PMC) Summary & key facts 2023 63 citations

This review combined 65 randomized trials with 5,048 adults who had generalized anxiety disorder. The authors found that cognitive behavioral therapy (CBT) was linked with better short-term and long-term outcomes than treatment as usual. Third‑wave CBTs and relaxation therapy were linked with short-term benefits, but after removing studies judged to…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Mental Health Research Topics

Safety and Efficacy of Repeated Low-Dose LSD for ADHD Treatment in Adults

Lorenz Mueller, Joyce Santos de Jesus, Yasmin Schmid, Felix Müller, A. Becker, Aaron Klaiber, et al.
JAMA Psychiatry Summary & key facts 2025 7 citations

This was a 6-week, double-blind, placebo-controlled trial that tested low-dose LSD (20 μg) given twice weekly in 53 adults with moderate to severe ADHD. Both the LSD group and the placebo group showed similar symptom reductions by week 6 (LSD mean change on the ADHD rating scale −7.1 points; placebo…

Attention Deficit Hyperactivity Disorder Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies
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