Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

7 papers

Post-Psychedelic Reductions in Experiential Avoidance Are Associated With Decreases in Depression Severity and Suicidal Ideation

Richard J. Zeifman, Anne Catherine Wagner, Ros Watts, Hannes Kettner, Lea J. Mertens, Robin Carhart‐Harris
Frontiers in Psychiatry Summary & key facts 2020 101 citations

Researchers followed two groups of people who planned to use a psychedelic. They gave questionnaires before the trip, then about two weeks and four weeks after. On average, people reported less avoidance of painful thoughts and feelings, lower depression scores, and less thinking about suicide after using a psychedelic. The…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies Other

The Unholy Trinity: Childhood Trauma, Adulthood Anxiety, and Long-Term Pain

Natália Kaščáková, Jana Fürstová, Jozef Hašto, Andrea Madarasová Gecková, Peter Tavel

This questionnaire study (2016–2017) compared a representative Czech sample (n = 1800, mean age 46.6, 48.7% male) and a clinical sample of patients with anxiety or adjustment disorder (n = 67, mean age 40.5, 18.0% male). People who reported childhood emotional abuse, emotional neglect, or physical neglect had higher odds…

Child Abuse and Trauma Child and Adolescent Health Migration, Health and Trauma

Gender Differences in the Relationship between Anger and Aggressive Behavior

Martha K. Fahlgren, Joey C. Cheung, Nicole K. Ciesinski, Michael S. McCloskey, Emil F. Coccaro

This study tested whether anger and aggressive actions are linked differently for men and women. Four hundred twenty-four adults did a behavioral aggression task, and 304 of them also answered questions about their typical anger. Men and women showed similar amounts of aggression overall. However, higher trait anger predicted more…

Bullying, Victimization, and Aggression Child and Adolescent Psychosocial and Emotional Development Intimate Partner and Family Violence

The role of protective self‐cognitions in the relationship between childhood trauma and later resource loss

Kristen H. Walter, Katie J. Horsey, Patrick A. Palmieri, Stevan E. Hobfoll
Journal of Traumatic Stress Summary & key facts 2010 27 citations

Researchers followed 402 inner-city women who had experienced childhood abuse. They looked at PTSD symptoms, two protective self-views (self-esteem and self-efficacy), and later resource loss. The study found that childhood abuse was linked to more PTSD symptoms and more resource loss later on. Higher PTSD symptoms were tied to lower…

Child Abuse and Trauma Migration, Health and Trauma Posttraumatic Stress Disorder Research

Risk of suicide and all-cause death in patients with mental disorders: a nationwide cohort study

Hyewon Kim, Jin‐Hyung Jung, Kyungdo Han, Hong Jin Jeon
Molecular Psychiatry Summary & key facts 2025 9 citations

This large South Korean study followed 3,951,398 adults for an average of 11.1 years to compare deaths in people with and without recorded mental disorders. After adjusting for age, sex, health conditions, income, smoking, drinking and physical activity, people with mental disorders had higher rates of suicide and higher overall…

Bipolar Disorder and Treatment Mental Health Treatment and Access Suicide and Self-Harm Studies

Psychedelic and nutraceutical interventions as therapeutic strategies for military-related mild traumatic brain injuries

Amy C. Reichelt, Eric Vermetten, Benjamin T. Dunkley

This review looks at studies on using classic psychedelics and nutraceuticals to treat concussion and lasting symptoms after mild traumatic brain injury. Concussion is common in the military, civilians, and contact sport players and usually causes temporary mental impairment, though a small minority have lasting problems. The authors report that…

Chemical synthesis and alkaloids Natural Compound Pharmacology Studies Psychedelics and Drug Studies

The Mediating Role of Emotional Dysregulation in the Relationship Between Anxious Attachment and Suicidal Behavior in Children Admitted to an Emergency Department

Oryan Cohen-Bausi, Oren Shahnovsky, Liat Haruvi-Catalan, Noa Benaroya-Milshtein, Silvana Fennig, Shira Barzilay

This study looked at 111 children aged 7–12 who came to a pediatric emergency department with suicidal thoughts or behaviors. It found that emotional dysregulation (trouble managing strong feelings) helped explain the link between an anxious attachment style toward parents and actual suicidal behaviors. The study did not find the…

Child and Adolescent Psychosocial and Emotional Development Maternal Mental Health During Pregnancy and Postpartum Suicide and Self-Harm Studies
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