Frontier mental health research: psychedelics & drug studies

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9 papers

Effects of Physical Exercise on Neuroplasticity and Brain Function: A Systematic Review in Human and Animal Studies

Matheus Santos de Sousa Fernandes, Tayrine Figueira Ordônio, Gabriela Carvalho Jurema Santos, Lucas Eduardo Rodrigues Santos, Camila Tenório Calazans, Dayane Aparecida Gomes, et al.
Neural Plasticity Summary & key facts 2020 177 citations

This 2020 systematic review looked at human and animal studies on physical exercise and brain plasticity. The authors screened 20,782 records and included 21 original studies. They reported that exercise was linked to higher levels of several neurotrophic factors and receptors, more cell growth and proliferation, and better measures of…

Attention Deficit Hyperactivity Disorder Children's Physical and Motor Development Neuroscience, Education and Cognitive Function

Cannabidiol for Treatment-Resistant Anxiety Disorders in Young People: An Open-Label Trial

Maximus Berger, Lei Li, Simon Rice, Christopher G. Davey, Aswin Ratheesh, Sophie Adams, et al.
PubMed Summary & key facts 2022 70 citations

This was a small open-label study of 31 young people (ages 12–25) whose anxiety had not improved with therapy or antidepressants. They took add-on cannabidiol (CBD) for 12 weeks, up to 800 mg per day, and average anxiety scores fell by about 42.6% over that time. Many participants had side…

Attention Deficit Hyperactivity Disorder Child and Adolescent Psychosocial and Emotional Development

Are Eating Disorders Related to Attention Deficit/Hyperactivity Disorder?

Shauna P. Reinblatt

This review says there is growing evidence of a link between ADHD and certain eating problems. The strongest links are with binge-eating behaviors and disorders that include bingeing and purging (bulimia nervosa, binge-eating disorder, and the binge–purge type of anorexia). Impulsivity is a likely but not proven part of the…

Attention Deficit Hyperactivity Disorder Eating Disorders and Behaviors Obsessive-Compulsive Spectrum Disorders

Neurophysiological activity following rewards and losses among female adolescents and young adults with borderline personality disorder.

Jeremy G. Stewart, Paris Singleton, Erik M. Benau, Dan Foti, Hannah Allchurch, Cynthia S. Kaplan, et al.
Journal of Abnormal Psychology Summary & key facts 2019 16 citations

This study recorded brain activity (EEG) while 68 females aged 13–23 (35 with borderline personality disorder, 33 healthy) did a guessing task with equal wins and losses. People with BPD showed less difference in their brain responses to wins versus losses than healthy peers. Time-frequency tests suggested this smaller difference…

Attention Deficit Hyperactivity Disorder Mental Health Research Topics Personality Disorders and Psychopathology

The relationship between individuals with fearful-avoidant adult attachment orientation and early neural responses to emotional content: An event-related potentials (ERPs) study.

Orrie Dan, Ghadir Zreik, Sivan Raz
Neuropsychology Summary & key facts 2019 16 citations

The study measured very early brain responses to emotional and neutral pictures in 119 undergraduate students (91 female, mean age 23.5 ± 3.6). It compared 30 fearful-avoidant people with 32 secure, 28 anxious-preoccupied, and 29 dismissive-avoidant participants. Fearful-avoidant individuals showed patterns in the early ERP components P1 (110–165 ms) and…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Attachment and Relationship Dynamics Attention Deficit Hyperactivity Disorder

Safety and Efficacy of Repeated Low-Dose LSD for ADHD Treatment in Adults

Lorenz Mueller, Joyce Santos de Jesus, Yasmin Schmid, Felix Müller, A. Becker, Aaron Klaiber, et al.
JAMA Psychiatry Summary & key facts 2025 7 citations

This was a 6-week, double-blind, placebo-controlled trial that tested low-dose LSD (20 μg) given twice weekly in 53 adults with moderate to severe ADHD. Both the LSD group and the placebo group showed similar symptom reductions by week 6 (LSD mean change on the ADHD rating scale −7.1 points; placebo…

Attention Deficit Hyperactivity Disorder Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies

The Biological Basis to Personality Disorders

Malathi Perugula, Puneet Narang, Steven Lippmann

This review looked at research on the biology of cluster B personality disorders (for example, borderline and antisocial types). Brain imaging studies report differences in areas that handle emotion and self-control, and emotional instability and impulsiveness are common features. The authors say genes and early-life experiences may contribute, psychotherapy is…

Attention Deficit Hyperactivity Disorder Mental Health and Psychiatry Personality Disorders and Psychopathology

What is the Most Helpful Body‐Scan Posture for People with Attention‐Deficit/Hyperactivity Disorder Tendency?

Ayano Fukuichi, Takafumi Wakita, Genji Sugamura

The authors made and checked two short scales (MERS and MDRS) to measure helpful or unhelpful reactions during mindfulness exercises. They used three small studies with university students (21, 192, and 19 people). In a small experiment, people with a hyperactive/impulsive tendency said slumped sitting felt harder and lying on…

Attention Deficit Hyperactivity Disorder Mindfulness and Compassion Interventions Sleep and related disorders
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