Frontier mental health research: psychedelics & drug studies

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19 papers

Emotion Dysregulation in Attention Deficit Hyperactivity Disorder

Philip Shaw, Argyris Stringaris, Joel T. Nigg, Ellen Leibenluft
American Journal of Psychiatry Summary & key facts 2014 1,128 citations

This review looked at research on emotion dysregulation (problems managing emotions) in people with ADHD. It found three main points: emotion dysregulation is common across the lifespan and causes substantial problems; it may come from trouble noticing, recognizing, or paying attention to emotional cues tied to a brain circuit that…

Attention Deficit Hyperactivity Disorder Mind wandering and attention Sleep and related disorders

Gender effects on Attention-Deficit/Hyperactivity disorder in adults, revisited

Joseph Biederman, Stephen V. Faraone, Michael C. Monuteaux, Marie Bober, Elizabeth Cadogen
Biological Psychiatry Summary & key facts 2004 380 citations

This study reexamined gender differences in adult ADHD by comparing 219 adults with ADHD to 215 control subjects matched for age and gender. The researchers found no evidence that gender changed how ADHD related to other psychiatric disorders. Adults with ADHD showed cognitive deficits and higher rates of major depression,…

Attention Deficit Hyperactivity Disorder Child and Adolescent Psychosocial and Emotional Development Functional Brain Connectivity Studies

Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation

Katya Rubia
Frontiers in Human Neuroscience Summary & key facts 2018 354 citations

Brain imaging studies (fMRI) show that ADHD is linked to problems in many brain networks that control attention, timing, working memory, motivation, and emotion. There is also evidence that a brain system normally quiet during tasks (the default mode network) does not switch off properly in people with ADHD. Some…

Attention Deficit Hyperactivity Disorder Functional Brain Connectivity Studies Transcranial Magnetic Stimulation Studies

ADHD and the Prefrontal Cortex

Amy F.T. Arnsten
The Journal of Pediatrics Summary & key facts 2009 198 citations

Research links ADHD — which shows up as inattention, impulsivity, and too much activity — to weaker structure and function in the brain’s prefrontal cortex (PFC), especially on the right side. The PFC helps control top-down attention, stop inappropriate actions, and regulate emotion, and it needs the right balance of…

Attention Deficit Hyperactivity Disorder Functional Brain Connectivity Studies Neural and Behavioral Psychology Studies

Effects of Physical Exercise on Neuroplasticity and Brain Function: A Systematic Review in Human and Animal Studies

Matheus Santos de Sousa Fernandes, Tayrine Figueira Ordônio, Gabriela Carvalho Jurema Santos, Lucas Eduardo Rodrigues Santos, Camila Tenório Calazans, Dayane Aparecida Gomes, et al.
Neural Plasticity Summary & key facts 2020 177 citations

This 2020 systematic review looked at human and animal studies on physical exercise and brain plasticity. The authors screened 20,782 records and included 21 original studies. They reported that exercise was linked to higher levels of several neurotrophic factors and receptors, more cell growth and proliferation, and better measures of…

Attention Deficit Hyperactivity Disorder Children's Physical and Motor Development Neuroscience, Education and Cognitive Function

Cannabinoids in attention-deficit/hyperactivity disorder: A randomised-controlled trial

Ruth Cooper, Emma Williams, Seth Seegobin, Charlotte Tye, Jonna Kuntsi, Philip Asherson
European Neuropsychopharmacology Summary & key facts 2017 165 citations

This small pilot randomized placebo‑controlled trial tested a cannabinoid spray (Sativex) in 30 adults with ADHD. The main test of cognition and activity (QbTest) showed no significant difference between Sativex and placebo in the intention‑to‑treat analysis (Estimate = -0.17, 95% CI -0.40 to 0.07, p = 0.16). Some secondary measures…

Attention Deficit Hyperactivity Disorder Bipolar Disorder and Treatment Cannabis and Cannabinoid Research

ADHD and depression: investigating a causal explanation

Lucy Riglin, Beate Leppert, Christina Dardani, Ajay K. Thapar, Ajay K. Thapar, Frances Rice, et al.
Psychological Medicine Summary & key facts 2020 138 citations

This study used a long-term UK birth cohort (N = 8,310) and genetic analyses to test whether childhood ADHD is linked to depression later in life. Children with ADHD at age 7 had higher odds of recurrent depression in young adulthood (OR 1.35, 95% CI 1.05–1.73). Genetic analyses (Mendelian randomization)…

Attention Deficit Hyperactivity Disorder Functional Brain Connectivity Studies Health, Environment, Cognitive Aging

Attention-deficit hyperactivity disorder (ADHD) stimulant medications as cognitive enhancers

Claire Advokat, Mindy Scheithauer
Frontiers in Neuroscience Summary & key facts 2013 62 citations

This review looked at studies of ADHD stimulant drugs (like methylphenidate and amphetamine). The drugs clearly reduce core ADHD symptoms for many people, but they do not reliably make ADHD students do better in school or on many cognitive tests in real-world settings. The drugs helped one type of memory…

Attention Deficit Hyperactivity Disorder Functional Brain Connectivity Studies Neuroethics, Human Enhancement, Biomedical Innovations

Efficacy of Cognitive Behavioral Therapy With and Without Medication for Adults With ADHD: A Randomized Clinical Trial

Mariya V. Cherkasova, L French, Cassidy A. Syer, Lorne S. Cousins, Harry Galina, Yasaman Ahmadi-Kashani, et al.
Journal of Attention Disorders Summary & key facts 2016 54 citations

This randomized clinical trial tested 12 sessions of manualized group cognitive behavioral therapy (CBT) with individual coaching in 88 adults with ADHD. Participants were randomly assigned to CBT alone (n = 46) or CBT plus medication (n = 42). The combined treatment produced greater improvements in ADHD symptoms, organizational skills,…

Attention Deficit Hyperactivity Disorder Behavioral and Psychological Studies Neural and Behavioral Psychology Studies

Screen time, impulsivity, neuropsychological functions and their relationship to growth in adolescent attention-deficit/hyperactivity disorder symptoms

Jasmina Wallace, Elroy Boers, Julien Ouellet, Mohammad H. Afzali, Patricia Conrod
Scientific Reports Summary & key facts 2023 47 citations

Researchers followed 3,779 Canadian adolescents (mean age 12.8 years, 49% girls) for five years and found that when a teen’s screen time went up in a given year, their ADHD symptoms tended to increase that same year. Impulsivity was the strongest link between screen time and ADHD symptoms. Only social…

Attention Deficit Hyperactivity Disorder Child Development and Digital Technology Impact of Technology on Adolescents

Self-Reported Effects of Cannabis on ADHD Symptoms, ADHD Medication Side Effects, and ADHD-Related Executive Dysfunction

Amanda Stueber, Carrie Cuttler
Journal of Attention Disorders Summary & key facts 2021 43 citations

The researchers surveyed 1,738 students about ADHD, cannabis use, and thinking skills. People with ADHD who had used cannabis said it gave them short-term benefits for many ADHD symptoms (for example, hyperactivity and impulsivity) and eased many medication side effects (for example, irritability and anxiety). The study also found that…

Attention Deficit Hyperactivity Disorder Bipolar Disorder and Treatment Child and Adolescent Psychosocial and Emotional Development
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