Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.
This review found that Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) share many symptoms and similar biological changes. People with both conditions often have long-lasting fatigue, thinking problems, sleep disruption, pain, post-exertional worsening, and signs of problems in the brain, autonomic nervous system, heart, lungs, immune system, gut microbiome,…
This study measured health-related quality of life (HRQoL) in Danish patients with ME/CFS using the EQ-5D-3L tool and found their scores were much lower than the general population and lower than 20 other conditions. The average (unadjusted) EQ-5D-3L score for the ME/CFS group was 0.47, while the population average was…
This paper compares how big the health and economic impact of ME/CFS is to how much the U.S. NIH spends on research. Using earlier prevalence data and 2017 funding figures, the authors estimate ME/CFS affects 1 to 2.5 million Americans, has a disease burden about twice that of HIV/AIDS and…
This review says that calling ME/CFS a psychosomatic illness does not fit current scientific evidence and harms patients. ME/CFS has been classed as a neurological disease since 1969. Studies report repeated physical abnormalities in blood flow, vascular function, energy metabolism, and immune markers, and many patients develop ME/CFS after an…
This paper reviews early evidence that raising body temperature in a controlled way — called whole-body hyperthermia — may affect brain problems seen in diseases like Alzheimer's, Parkinson's, Huntington's and in some cases of Long COVID. Heating the body to fever-like levels can boost special protective proteins (heat shock proteins),…
