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4 papers
This paper is a careful review of research about treatment-resistant depression. The authors looked through medical studies to see how doctors define this kind of depression, what makes it hard to assess, and which treatments have been tried. They describe drug strategies like adding lithium or thyroid hormone, switching antidepressant…
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent and serious neurodevelopmental disorder characterized by symptoms of inattention and/or hyperactivity/impulsivity. Chronic and childhood stress is involved in ADHD development, and ADHD is highly comorbid with anxiety. Similarly, inflammatory diseases and a pro-inflammatory state have been associated with ADHD. However, while several works have…
This review looks at research on psychedelic drugs, especially psilocybin. It says recent human studies show a single dose can give lasting relief from severe depression, and regulators have given two late-stage psilocybin trials special 'Breakthrough Therapy' status. The paper also pulls together lab and animal studies that suggest psychedelics…
This paper notes that recreational ketamine use is becoming more common and can cause serious, often irreversible, damage to the urinary tract. The authors describe a young man who had used ketamine for 5 years and had 2 years of troublesome lower urinary tract symptoms. They say medical treatment is…
