Frontier mental health research: psychedelics & drug studies

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13 papers

Why do people with anxiety disorders become depressed? A prospective‐longitudinal community study

Hans‐Ulrich Wïttchen, Ronald C. Kessler, Hildegard Pfister, Michael Höfler, R. Lieb
Acta Psychiatrica Scandinavica Summary & key facts 2000 442 citations

In a community study of 3,021 adolescents and young adults followed for 4–5 years, researchers used structured interviews (DSM‑IV CIDI) and found that most anxiety disorders (except panic disorder) began before depression and were linked to a higher chance of later major depression. Rates of people having both anxiety and…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Maternal Mental Health During Pregnancy and Postpartum

Treatment of post-partum depression: a review of clinical, psychological and pharmacological options

Kristin Leight, Elizabeth Fitelson, Sarah Kim, Allison S. Baker

Postpartum depression (PPD) is a common problem after childbirth. Most studies find rates around 10%–15% in high-income countries, and rates can be much higher in poorer settings. Untreated PPD is linked with problems in mother–baby bonding and with worse child development. Screening in routine obstetric, pediatric, or primary care visits…

Breastfeeding Practices and Influences Child and Adolescent Psychosocial and Emotional Development Maternal Mental Health During Pregnancy and Postpartum

Maternity Blues: A Narrative Review

Valentina Tosto, Margherita Ceccobelli, Emanuela Lucarini, Alfonso Tortorella, Sandro Gerli, Fabio Parazzini, et al.

Maternity blues, also called baby blues, are short-lived mood changes after childbirth that can include tearfulness, irritability, anxiety, sleep and concentration problems. A recent review reports an overall prevalence of about 39% (studies ranged from 13.7% to 76%), but definitions and measurements vary widely. Symptoms usually start in the first…

Child and Adolescent Psychosocial and Emotional Development Infant Development and Preterm Care Maternal Mental Health During Pregnancy and Postpartum

Associations between perfectionism and symptoms of anxiety, obsessive-compulsive disorder and depression in young people: a meta-analysis

Jessica Lunn, Danyelle Greene, Thomas Callaghan, Sarah J. Egan
Cognitive Behaviour Therapy Summary & key facts 2023 49 citations

This meta-analysis combined 121 studies (from 4,927 articles found) about young people aged 6–24 (pooled mean age ≈ 17.7 years). It found that perfectionistic concerns (worry about making mistakes, fear of negative evaluation) were moderately linked to more symptoms of anxiety (r = .37–.41), OCD (r = .42), and depression…

Child and Adolescent Psychosocial and Emotional Development Maternal Mental Health During Pregnancy and Postpartum Perfectionism, Procrastination, Anxiety Studies

Prevalence of depressive symptoms in late pregnancy and postpartum

Ann Josefsson, Göran Berg, Conny Nordin, Gunilla Sydsjö

Many people have mood or anxiety problems during pregnancy and in the year after birth. About a quarter of people develop a perinatal mood or anxiety disorder, and these can include postpartum depression, anxiety, OCD, PTSD, and, rarely, psychosis. These conditions are often not diagnosed, but studies and clinical guidance…

Adolescent and Pediatric Healthcare Family Support in Illness Maternal Mental Health During Pregnancy and Postpartum

Brexanolone to Treat Postpartum Depression in Adult Women

Elyse M. Cornett, Lauren Rando, Austin M Labbé, Wil Perkins, Adam M. Kaye, Alan D. Kaye, et al.
Psychopharmacology Bulletin Summary & key facts 2025 32 citations

Brexanolone (brand name ZULRESSO) is an FDA-approved drug for moderate-to-severe postpartum depression. In trials it reduced depressive symptoms quickly and had mostly mild side effects, but it is given by IV in a monitored inpatient setting because it can cause heavy sleepiness and even loss of consciousness. It is not…

Maternal Mental Health During Pregnancy and Postpartum Neuroendocrine regulation and behavior Stress Responses and Cortisol

A Meta-analysis of Mindfulness-Based Interventions in Adults with Attention-Deficit Hyperactivity Disorder: Impact on ADHD Symptoms, Depression, and Executive Functioning

Hélène Poissant, Alexander Moreno, Stéphane Potvin, Adriana Mendrek
Mindfulness Summary & key facts 2020 32 citations

This study combined results from 14 research papers to see whether mindfulness programs help adults with ADHD. The pooled data covered 834 adults and came from searches of PsycINFO, PubMed, SCOPUS, and ERIC up to July 2019. Overall, the meta-analysis found that mindfulness-based interventions reduced ADHD symptoms, lowered depression, and…

Attention Deficit Hyperactivity Disorder Maternal Mental Health During Pregnancy and Postpartum Mindfulness and Compassion Interventions

Anger in the context of postnatal depression: An integrative review

Christine Ou, Wendy A. Hall
Birth Summary & key facts 2018 32 citations

A University of British Columbia review published in Birth found that anger often occurs alongside postnatal depression. The review says anger can be aimed at the self, the baby, or family members and can harm relationships. It links anger to feeling powerless, unmet expectations about motherhood, and lack of support.…

Child and Adolescent Psychosocial and Emotional Development Grief, Bereavement, and Mental Health Maternal Mental Health During Pregnancy and Postpartum

Postpartum Depression: Etiology, Treatment, and Consequences for Maternal Care

Daiana Anne‐Marie Dimcea, Răzvan Petca, Mihai Cristian Dumitrașcu, Florica Şandru, Claudia Mehedințu, Aida Petca
Diagnostics Summary & key facts 2024 31 citations

This review says postpartum depression (PPD) is a common and disabling problem that has been rising in many places. It summarizes known risk factors in social and economic life, childbirth history, lifestyle, and past mental illness. The paper also reviews biological and genetic work (the serotonin transporter gene, SERT, is…

Child and Adolescent Psychosocial and Emotional Development Maternal Mental Health During Pregnancy and Postpartum Neuroendocrine regulation and behavior

Correlates of Canadian mothers’ anger during the postpartum period: a cross-sectional survey

Christine Ou, Wendy A. Hall, Paddy Rodney, Robyn Stremler
BMC Pregnancy and Childbirth Summary & key facts 2022 15 citations

This study surveyed 278 Canadian mothers of healthy infants aged 6–12 months about sleep, mood, and anger. About 31% reported intense current anger, 26% had probable postpartum depression, and 52% said their sleep was poor. Statistical analysis found that mothers' own sleep quality and how angry they felt about their…

Infant Development and Preterm Care Maternal and Perinatal Health Interventions Maternal Mental Health During Pregnancy and Postpartum

Relationship between depressive symptoms and anemia among the middle-aged and elderly: a cohort study over 4-year period

Congqi Liu, Ruihao Zhou, Xilin Peng, Tao Zhu, Wei Wei, Xuechao Hao
BMC Psychiatry Summary & key facts 2023 13 citations

This study used China’s CHARLS data from 2011 and 2015 to look at people aged 45 and older. In 10,179 people at baseline, higher depressive symptom scores were linked to lower hemoglobin and to having anemia. Over 4 years (5,887 people followed), people with depressive symptoms had higher odds of…

Health disparities and outcomes Maternal Mental Health During Pregnancy and Postpartum Optimism, Hope, and Well-being

The relationship between family support system with maternal postpartum rage

Miftahul Fikri, Neviyarni Neviyarni, Afdal Afdal

This cross-sectional study surveyed 121 young mothers in West Sumatra who had children aged 1 to 24 months. The researchers used the Edinburgh Postnatal Depression Scale (EPDS) and a social support scale. They found first-time mothers had higher postpartum rage than mothers with a second or third child. The paper…

Global Socioeconomic and Political Dynamics Maternal Mental Health During Pregnancy and Postpartum
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