Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.
Some research suggests that whole-plant cannabis compounds (like THC, CBD, other cannabinoids, terpenes, and flavonoids) can interact so the plant’s effects differ from CBD alone. Healthline explains three CBD types — full-spectrum, broad-spectrum, and isolate — and notes legal, safety, and labeling limits. The article says there is evidence for…
This laboratory study found that cannabidiol (CBD), a non‑psychoactive compound from Cannabis sativa, reduced fat production and inflammation in human sebaceous (oil) gland cells. The effects were seen in cultured human sebocytes and in human skin organ cultures, where CBD blocked the fat‑making (lipogenic) actions of several compounds. These results…
Microdosing means taking a very small, sub‑hallucinogenic amount of a psychedelic drug. Research so far is limited and mixed: some large observational studies report small-to-medium mood gains, but at least one randomized trial found no objective benefit. There is no standard definition of microdosing, potency and legality vary, and long‑term…
This paper reviews the recent comeback of psychedelic research and points out that much of that work borrows from indigenous healing traditions. The authors say Indigenous people, ethnic and racial minorities, women, and other marginalized groups are often left out of research and the mainstream story about psychedelic medicine. The…
This is a short 1970 Nature paper by E. W. Gill, W. D. Paton and R. G. Pertwee that reports preliminary experiments on the chemistry and pharmacology of cannabis. The PubMed entry has no abstract, but its indexing shows the paper looked at drug effects and toxicity, and at topics…
Researchers isolated a new natural cannabis compound called Δ9-tetrahydrocannabiphorol (Δ9-THCP) and its CBD counterpart (CBDP). In lab tests, Δ9-THCP bound very strongly to the human CB1 receptor (Ki = 1.2 nM) and caused THC-like effects in mice (less movement, pain relief, catalepsy, and lower body temperature). The authors say Δ9-THCP…
Researchers used a large prospective online survey to test whether psychedelic drug use changes people’s metaphysical beliefs. After psychedelic use, people tended to move away from physicalist or materialist views and toward panpsychism and fatalism. Except for fatalism, these shifts lasted for at least 6 months. The shifts were linked…
Hallucinogen Persisting Perception Disorder, or HPPD, is a rare condition tied to using hallucinogenic drugs. People with HPPD keep having changes in how they see things after the drug wears off. It is diagnosed more often in people who already had mental health problems or problems with drug use, but…
Renewed interest in the effects of psychedelics in the treatment of psychiatric disorders warrants a better understanding of the neurobiological mechanisms underlying the effects of these substances. During the past two decades, state-of-the-art studies of animals and humans have yielded new important insights into the molecular, cellular, and systems-level actions…
This study used a smartphone app to compare 4,050 people who said they microdose psychedelics with 4,653 people who did not. Psilocybin was the most common microdose substance, and people who microdosed often said they did so for health and wellness reasons. In people who reported past mental health concerns,…
This paper reviews human and animal research on so-called psychedelics (like psilocybin and LSD) and entactogens (mainly MDMA). The authors say these drugs can produce fast improvements in mental health that sometimes last for months or longer. But we do not yet understand exactly how they work. Human studies point…
Researchers ran a national online survey of U.S. adults from November 2020 to March 2021 that was weighted to represent the adult population. They asked about use of psychedelic mushrooms (psilocybin), reasons for use, and mental health. Many users said they took mushrooms for general mental health and well-being. Users…
