Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

4 papers

The effects of physical activity on cortisol and sleep: A systematic review and meta-analysis

Len De Nys, Kerry Anderson, Esther Frema Ofosu, Gemma C. Ryde, Jenni Connelly, Anna C. Whittaker
Psychoneuroendocrinology Summary & key facts 2022 227 citations

This review combined results from 10 intervention studies to see if physical activity programs change cortisol (a stress hormone) and sleep in adults. The pooled results found lower cortisol after activity programs and some improvement in sleep quality. The authors say the evidence is moderate for cortisol and low for…

Circadian rhythm and melatonin Physical Activity and Health Sleep and related disorders

The role of sleep in bipolar disorder

Alexandra K Gold, Louisa G Sylvia
www.dovepress.com Summary & key facts 2016 144 citations

Sleep problems are very common in bipolar disorder, which affects about 1% of people in their lifetime. Research suggests these problems relate to disruptions in both the body’s internal clock (circadian system, “process C”) and the sleep–wake drive (homeostasis, “process S”), though this is not proven to be the single…

Bipolar Disorder and Treatment Circadian rhythm and melatonin Sleep and related disorders

Interactions between Stress and Vestibular Compensation – A Review

Yougan Saman, Doris‐Eva Bamiou, Michael Gleeson, Mayank B. Dutia
Frontiers in Neurology Summary & key facts 2012 80 citations

This review looked at studies in animals and people about how stress and the balance system (the vestibular system) affect each other. In many animal experiments, vestibular damage or stimulation turns on the body's stress system (the HPA axis) and short-term stress hormones help brain circuits adjust after vestibular loss.…

Circadian rhythm and melatonin Stress Responses and Cortisol Vestibular and auditory disorders

Modified Cortisol Circadian Rhythm: The Hidden Toll of Night-Shift Work

Aikaterini Andreadi, Stella Andreadi, Federica Todaro, Lorenzo Ippoliti, Alfonso Bellia, Andrea Magrini, et al.

This 2025 narrative review explains that cortisol normally peaks in the early morning and falls to its lowest levels in the early night. Night-shift work often shifts or flattens that pattern, causing a blunted or delayed morning peak and a less steep decline through the day. The authors link this…

Circadian rhythm and melatonin Climate Change and Health Impacts Stress Responses and Cortisol
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