Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

32 papers

Mindfulness-Based Stress Reduction for Stress Management in Healthy People: A Review and Meta-Analysis

Alberto Chiesa, Alessandro Serretti

MBSR is able to reduce stress levels in healthy people. However, important limitations of the included studies as well as the paucity of evidence about possible specific effects of MBSR in comparison to other nonspecific treatments underline the necessity of further research.

COVID-19 and Mental Health Mindfulness and Compassion Interventions Resilience and Mental Health

A Randomized Controlled Effectiveness Trial of Acceptance and Commitment Therapy and Cognitive Therapy for Anxiety and Depression

Evan M. Forman, James D. Herbert, Ethan Moitra, Peter D. Yeomans, Pamela A. Geller
Behavior Modification Summary & key facts 2007 682 citations

The source explains what Acceptance and Commitment Therapy (ACT) is and reports research comparing ACT with cognitive therapy (CT). In a randomized trial of 101 outpatients with moderate to severe anxiety or depression, people assigned to ACT or to CT showed large, similar improvements in depression, anxiety, daily functioning, quality…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Complementary and Alternative Medicine Studies Mindfulness and Compassion Interventions

Brief structured respiration practices enhance mood and reduce physiological arousal

Melis Yilmaz Balban, Eric Neri, Manuela M. Kogon, Lara Weed, Bita Nouriani, Booil Jo, et al.
Summary & key facts 226 citations

In a remote, randomized trial (NCT05304000), people did one of three five-minute daily breathing exercises or five minutes of mindfulness meditation each day for one month. The researchers measured mood, anxiety, and physiological arousal (breathing rate, heart rate, and heart rate variability). Breathwork—especially exhale-focused cyclic sighing—produced bigger mood gains and…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes COVID-19 and Mental Health Mindfulness and Compassion Interventions

Meditation and yoga for posttraumatic stress disorder: A meta-analytic review of randomized controlled trials

Autumn M. Gallegos, Hugh F. Crean, Wilfred R. Pigeon, Kathi L. Heffner
Clinical Psychology Review Summary & key facts 2017 178 citations

This paper pooled results from 19 randomized trials with 1,173 adults to see if meditation and yoga change PTSD symptoms. Overall, these mind–body practices were linked to a small-to-medium reduction in PTSD symptoms (effect size = −0.39). The authors found no big differences by type of practice, who was studied,…

Mindfulness and Compassion Interventions Posttraumatic Stress Disorder Research Resilience and Mental Health

Breathing‐Based Meditation Decreases Posttraumatic Stress Disorder Symptoms in U.S. Military Veterans: A Randomized Controlled Longitudinal Study

Emma Seppälä, Jack B. Nitschke, Dana Tudorascu, Andrea S Hayes, Michael R. Goldstein, Dong T. H. Nguyen, et al.
Journal of Traumatic Stress Summary & key facts 2014 177 citations

This randomized study tested a breathing-based meditation (Sudarshan Kriya yoga) in 21 male U.S. veterans of the Iraq or Afghanistan wars. Participants were randomly assigned to the meditation group (n = 11) or a waitlist control (n = 10). The meditation group showed reductions in self-reported PTSD symptoms, anxiety, and…

Mindfulness and Compassion Interventions Posttraumatic Stress Disorder Research Stress Responses and Cortisol

Stress: Neurobiology, consequences and management

Anil Kumar, Puneet Rinwa, Gurleen Kaur, Lalit Machawal

This 2013 review explains how physical and psychological stress change the brain and body. It describes how stress activates the HPA (hypothalamic–pituitary–adrenal) system and alters brain chemicals such as GABA, dopamine, norepinephrine and serotonin. The paper also covers short-term memory effects, animal models used to study chronic stress, and both…

Medicinal Plants and Neuroprotection Mindfulness and Compassion Interventions Stress Responses and Cortisol

Mindful awareness in body-oriented therapy as an adjunct to women’s substance use disorder treatment: a pilot feasibility study

Cynthia Price, Elizabeth A. Wells, Dennis M. Donovan, Tessa Rue
PubMed Summary & key facts 2012 90 citations

This small randomized pilot study tested a therapy called Mindful Awareness in Body-Oriented Therapy (MABT) as an extra treatment for women in substance use disorder (SUD) care. Forty-six women were enrolled and those in the MABT group received eight weekly one-on-one sessions in addition to usual care. At the main…

Eating Disorders and Behaviors Mindfulness and Compassion Interventions Psychosomatic Disorders and Their Treatments

The Only Way Out Is Through: The Peril of Spiritual Bypass

Craig S. Cashwell, Paige Bentley, J. Preston Yarborough
Counseling and Values Summary & key facts 2007 63 citations

Given the increased attention to spirituality in the counseling literature, with a primary emphasis on helping clients find their spiritual path, it is important for counselors to be aware of one potential pitfall of the spiritual path, namely spiritual bypass . Spiritual bypass occurs when clients seek to use their…

Mindfulness and Compassion Interventions Religion, Spirituality, and Psychology Workplace Spirituality and Leadership

Mindful walking in psychologically distressed individuals: a randomized controlled trial

Michael Teut, E. J. Roesner, Miriam Ortiz, Frauke Reese, Sylvia Binting, Stephanie Roll, et al.
PubMed Summary & key facts 2013 50 citations

This randomized trial put 74 adults with moderate-to-high perceived stress into either an 8-session mindful walking program over 4 weeks or a waiting-list control. After 4 weeks, the mindful walking group had a much larger drop in perceived stress scores than the control group. The study also reported better quality-of-life…

Art Therapy and Mental Health Mindfulness and Compassion Interventions Psychosomatic Disorders and Their Treatments

Neurobiological Changes Induced by Mindfulness and Meditation: A Systematic Review

Andrea Calderone, Dèsiréè Latella, Federica Impellizzeri, Paolo De Pasquale, Fausto Famà, Angelo Quartarone, et al.
Biomedicines Summary & key facts 2024 49 citations

This systematic review of research up to 2024 found that meditation and mindfulness are linked to measurable brain changes and to better emotional regulation, cognition, and stress resilience. Many studies report thicker cortex in certain areas, lower amygdala reactivity, changes in brain connectivity and neurotransmitters, and improvements in anxiety, depression,…

Mindfulness and Compassion Interventions Music Therapy and Health Sleep and related disorders

Pranayamas and their neurophysiological effects

Stephany Campanelli, AdrianoBretanha Lopes Tort, Bruno Lobão‐Soares
International Journal of Yoga Summary & key facts 2020 37 citations

This 2020 review looked at English studies on yogic breathing (pranayamas) published from 2008 to 2018. The authors screened 1,588 articles and analyzed 14 that met their criteria. Those 14 papers generally reported effects of pranayama on emotional states and on thinking or cognitive performance. The review also said the…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Heart Rate Variability and Autonomic Control Mindfulness and Compassion Interventions
Summaries and links are for general information and education only. They are not a substitute for reading the original publication or for professional medical, legal, or other advice. Always refer to the linked source for the full study.