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Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

Tryptophan and brain disorders Statistics

3 papers

Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial

Jennifer L. Phillips, Sandhaya Norris, Jeanne Talbot, Meagan Birmingham, Taylor Hatchard, Abigail Ortiz, et al.
American Journal of Psychiatry Summary & key facts 2019 396 citations

Repeated ketamine infusions have cumulative and sustained antidepressant effects. Reductions in depressive symptoms were maintained among responders through once-weekly infusions. These findings provide novel data on efficacious administration strategies for ketamine in patients with treatment-resistant depression. Future studies should further expand on optimizing administration to better translate the use of…

Mental Health Research Topics Treatment of Major Depression Tryptophan and brain disorders

Long-term outcomes of repeated ketamine infusions in patients with unipolar and bipolar depression: A naturalistic follow-up study

Weicheng Li, Yanling Zhou, Weijian Liu, Chengyu Wang, Xiaofeng Lan, Zhipei Zhang, et al.
Journal of Affective Disorders Summary & key facts 2021 13 citations

Researchers followed 108 people with unipolar or bipolar depression who had repeated ketamine infusions (three times weekly over 12 days) and then were observed for 9 months. Depression symptoms and overall function were measured with the PHQ‑9 and the GAF. Seventy‑one people (65.7%) completed the full 9‑month follow‑up. At month…

Mental Health Research Topics Treatment of Major Depression Tryptophan and brain disorders

Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial

Jennifer L. Phillips, Sandhaya Norris, Jeanne Talbot, Meagan Birmingham, Taylor Hatchard, Abigail Ortiz, et al.
FOCUS The Journal of Lifelong Learning in Psychiatry Summary & key facts 2020 8 citations

(Reprinted with permission from The American Journal of Psychiatry 2019; 176:401-409).

Mental Health Research Topics Treatment of Major Depression Tryptophan and brain disorders
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