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In a randomized trial, 98 adults with treatment-resistant depression had brain scans before and 24 hours after a single intravenous infusion of ketamine (0.5 mg/kg) or saline. The researchers measured mean diffusivity (DTI-MD), an MRI-based, indirect marker of microstructural brain change that tends to fall when new synapses or tissue…
This paper is a systematic review and meta-analysis of resting-state fMRI studies that compared people with diagnosed anxiety disorders to healthy controls. The authors searched 1,226 records and then ran a coordinate-based meta-analysis (ALE) only on seed-based rs-fMRI studies because other study types were too few. The meta-analysis found reduced…
