Frontier mental health research: psychedelics & drug studies

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6 papers

Sex differences in anxiety and depression: Role of testosterone

Jenna A. McHenry, Nicole Carrier, Elaine M. Hull, Mohamed Kabbaj
Frontiers in Neuroendocrinology Summary & key facts 2013 487 citations

This review examines studies on how testosterone relates to anxiety and depression and how that might help explain sex differences in these disorders. About 18% of U.S. adults have an anxiety disorder each year and about 7% have major depressive disorder, and women are more than twice as likely as…

Hormonal and reproductive studies Neuroendocrine regulation and behavior Stress Responses and Cortisol

Antidepressant-associated sexual dysfunction: impact, effects, and treatment

Agnès Higgins

This review says sexual problems are common side effects of many antidepressant medicines. The exact chance varies a lot between studies. Problems can include lower sex drive, less excitement, delayed or lost orgasms, and erection or ejaculation trouble. Some drugs (many SSRIs and venlafaxine) often show high rates, while others…

Hormonal and reproductive studies Sexual function and dysfunction studies Treatment of Major Depression

Testosterone in Female Depression: A Meta-Analysis and Mendelian Randomization Study

Dhruba Tara Maharjan, Ali Alamdar Shah Syed, Guan Ning Lin, Weihai Ying
Biomolecules Summary & key facts 2021 28 citations

This paper combined past studies (a meta-analysis) and a genetic test (Mendelian randomization) to look at blood testosterone and depression in women. The meta-analysis found that women with depression have significantly different serum testosterone levels than healthy women, with a clear result in premenopausal women and weaker (borderline) results in…

Hormonal and reproductive studies Hypothalamic control of reproductive hormones Stress Responses and Cortisol

Antidepressant-associated sexual dysfunction in outpatients

Yasir Şafak, Sena Inal Azizoglu, Furkan Bahadır Alptekin, Tacettin Kuru, Mehmet Emrah Karadere, Şule Kaya, et al.
BMC Psychiatry Summary & key facts 2025 13 citations

This study asked 452 outpatients in Türkiye who had used one antidepressant for at least one month about sexual problems. Using a standard questionnaire, researchers found very high rates of self-reported sexual dysfunction: 88.7% of women and 84.5% of men. Women taking bupropion reported lower levels of sexual dysfunction than…

Hormonal and reproductive studies Sexual function and dysfunction studies Urinary Bladder and Prostate Research

Post-SSRI sexual dysfunction: barriers to quantifying incidence and prevalence

David Healy, Dee Mangin

Post-SSRI sexual dysfunction (PSSD) is a condition where sexual problems start with SSRIs or related antidepressants and keep going after the medicine is stopped. Common symptoms are genital numbness, weak or pleasureless orgasms, low libido, and erectile problems. Researchers say we do not know how common PSSD is because studies…

Hormonal and reproductive studies Menopause: Health Impacts and Treatments Sexual function and dysfunction studies

Role of serotonin, estrogen, and TNF‐α in the paroxetine‐impaired steroidogenesis and testicular macrophages polarization

Flávia L. Beltrame, Thiago Henrique Pereira Moysés, Mônica Pereira Coelho, Maria Clara Rossetto Steinvascher, Salmo Azambuja de Oliveira, André Acácio Souza da Silva, et al.
Andrology Summary & key facts 2023 3 citations

The Scott Trust, Guardian Media Group (GMG) and The Scott Trust Endowment Limited (STEL) published a modern slavery statement for the year ending 31 March 2025. It says they use policies, supplier checks, contract clauses, training and investment oversight to try to lower the risk of modern slavery in their…

Hormonal and reproductive studies Hormonal Regulation and Hypertension Stress Responses and Cortisol
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