Frontier mental health research: psychedelics & drug studies

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12 papers

Caught in the thickness of brain fog: exploring the cognitive symptoms of Chronic Fatigue Syndrome

Anthony J. Ocon
Frontiers in Physiology Summary & key facts 2013 151 citations

Chronic Fatigue Syndrome (CFS) is defined as more than 6 months of new, disabling physical and mental tiredness that is not relieved by rest. Up to about 85% of people with CFS report cognitive problems called “brain fog,” described as slow thinking, trouble focusing, confusion, forgetfulness, or a hazy mind.…

Fibromyalgia and Chronic Fatigue Syndrome Research Musculoskeletal pain and rehabilitation Olfactory and Sensory Function Studies

Therapeutic Effect and Mechanisms of Essential Oils in Mood Disorders: Interaction between the Nervous and Respiratory Systems

T.K.H. Fung, Benson Wui-Man Lau, Shirley P.C. Ngai, Hector W. H. Tsang

Essential oils (EOs) are extracted from plants and contain active components with therapeutic effects. Evidence shows that various types of EOs have a wide range of health benefits. In our previous studies, the potential of lavender EO for prevention and even treatment of depression and anxiety symptoms was demonstrated. The…

Neurogenesis and neuroplasticity mechanisms Olfactory and Sensory Function Studies Sleep and Wakefulness Research

Effects of aromatherapy on anxiety: A meta-analysis of randomized controlled trials

Minmin Gong, Hui Dong, Yueheng Tang, Wenya Huang, Fuer Lu
PubMed Summary & key facts 2020 115 citations

This meta-analysis combined 32 randomized trials from 25 articles to see if aromatherapy lowers anxiety. It found that both inhalation and massage aromatherapy were linked with lower scores on a common anxiety scale (STAI). The review noted no reported side effects, but said more research is needed on the right…

Olfactory and Sensory Function Studies

Anxiolytic Terpenoids and Aromatherapy for Anxiety and Depression

Snežana Agatonović-Kuštrin, Ella Kustrin, Vladimir Gegechkori, David W. Morton
PubMed Summary & key facts 2020 106 citations

This 2020 review looks at terpenoids in essential oils and how they might help with anxiety and depression. Animal studies reported that some essential oils and components like linalool reduce anxiety-like behavior. The authors suggest these effects likely come from changes in glutamate and GABA brain signaling. They also note…

Advanced Chemical Sensor Technologies Essential Oils and Antimicrobial Activity Olfactory and Sensory Function Studies

The Effects of Essential Oils on the Nervous System: A Scoping Review

Apsorn Sattayakhom, Sineewanlaya Wichit, Phanit Koomhin
Molecules Summary & key facts 2023 101 citations

This scoping review looked at research from 2012–2022 on how essential oils affect the nervous system. The authors included about 70 studies in humans, animals, and cell models. Across these studies, different oils (especially lavender and citrus) and mostly inhalation methods were linked to effects on stress, sleep, mood, pain,…

Essential Oils and Antimicrobial Activity Medicinal Plant Extracts Effects Olfactory and Sensory Function Studies

The Effect of Aromatherapy on Anxiety in Patients

Farzaneh Barati, Ahmad Nasiri, Negarin Akbari, Gholamreza Sharifzadeh
Nephro-Urology Monthly Summary & key facts 2016 75 citations

This randomized trial tested rose water inhalation in 46 hemodialysis patients. One group inhaled rose water for 4 weeks and the other group had no intervention. After 4 weeks the treated group had lower average state and trait anxiety scores, and the reductions were statistically significant (P < 0.001). The…

Complementary and Alternative Medicine Studies Fibromyalgia and Chronic Fatigue Syndrome Research Olfactory and Sensory Function Studies

Plant-derived nootropics and human cognition: A systematic review

Cristina Lorca, María Mulet, Catalina Arévalo‐Caro, Marco A. Piña Sánchez, Ainhoa Perez, María Perrino, et al.

This systematic review examined human studies of plant-derived nootropics across six cognitive domains. It included 256 papers published from January 2000 to November 2021 found via PubMed, Cochrane and Scopus. The review reports that Ginkgo biloba was most relevant for perceptual and motor functions, Bacopa monnieri improved language, learning and…

Medicinal Plants and Neuroprotection Neuroinflammation and Neurodegeneration Mechanisms Olfactory and Sensory Function Studies

Stress as a trigger for headaches: Relationship between exposure and sensitivity

Paul R. Martin, Lidia Lae, John Reece
Anxiety Stress & Coping Summary & key facts 2007 36 citations

This Healthline article explains a body-based method called shaking therapy (also called TRE or neurogenic tremoring). It says some experts believe gentle shaking can help the nervous system release tension and calm stress. The article gives simple ways to try it, notes possible benefits people report, and also clearly says…

Migraine and Headache Studies Musculoskeletal pain and rehabilitation Olfactory and Sensory Function Studies

Individual differences in visual motion perception and neurotransmitter concentrations in the human brain

Tatsuto Takeuchi, Sanae Yoshimoto, Yasuhiro Shimada, Takanori Kochiyama, Hirohito M. Kondo

The study tested why people differ in how they see motion. Participants viewed the same moving images but some reported motion assimilation and others motion contrast. The researchers measured brain chemicals with magnetic resonance spectroscopy and found that higher levels of the excitatory chemical glutamate–glutamine (Glx) in the dorsolateral prefrontal…

Neurobiology and Insect Physiology Research Olfactory and Sensory Function Studies Visual perception and processing mechanisms

A multisensory mindfulness experience: exploring the promotion of sensory awareness as a mindfulness practice

Finck, Carolyn, Avila, Alba, Jiménez-Leal, William, et al.
www.frontiersin.org Summary & key facts 2023 10 citations

This was a small, preliminary study that tested two short mindfulness setups: (a) an audio-only guided practice and (b) a multisensory experience (smell, sound, light) followed by a biofeedback display of the user’s heartbeat. Sixty-eight people took part. Heart-rate variability (HRV) data showed an increase in parasympathetic activity after the…

Mindfulness and Compassion Interventions Olfactory and Sensory Function Studies Urban Green Space and Health

Comforting delusions? How to evaluate the plausibility of mystical-type insights in psychedelic experiences

Jussi Jylkkä
Philosophical Psychology Summary & key facts 2024 8 citations

The paper says that psychedelics can produce mystical-type beliefs, like the idea that reality is a loving consciousness. The author argues we should not call these beliefs delusional just because they clash with naturalism (the view that only natural stuff exists). Instead, the paper recommends “metaphysical agnosticism” — holding off…

Complementary and Alternative Medicine Studies Olfactory and Sensory Function Studies Psychedelics and Drug Studies

“Neuroaromatics” : Aromatherapy and the Limbic Stress Response

H. G. M. D. Rathnayake

This review explains that smells reach the limbic brain very quickly and can change emotional and stress responses. It highlights evidence that certain essential oils — especially lavender, bergamot, and rose — can alter brain chemistry, lower stress hormones, and shift autonomic markers within minutes. Some studies reported cortisol drops…

Olfactory and Sensory Function Studies
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