Frontier mental health research: psychedelics & drug studies

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26 papers

Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic

COVID-19 Mental Disorders Collaborators
PubMed Central (PMC) Summary & key facts 2021 5,135 citations

This study reviewed surveys and used global models to measure how the COVID-19 pandemic changed rates of major depressive disorder and anxiety disorders in 2020. It found that places with higher COVID-19 infection rates and bigger drops in movement had larger increases in these disorders. The authors estimate about 53.2…

COVID-19 and Mental Health Health disparities and outcomes Long-Term Effects of COVID-19

Risks of all-cause and suicide mortality in mental disorders: a meta-review

Edward Chesney, Guy M. Goodwin, Seena Fazel
World Psychiatry Summary & key facts 2014 2,040 citations

This study reviewed systematic reviews to measure death risks in major mental disorders. The authors screened 407 reviews and found 20 that reported mortality risks for 20 different disorders, covering over 1.7 million patients and more than a quarter of a million deaths. Every disorder showed higher all-cause death rates…

Bipolar Disorder and Treatment Mental Health Treatment and Access Suicide and Self-Harm Studies

Review of the burden of eating disorders: mortality, disability, costs, quality of life, and family burden

Daphne van Hoeken, Hans W. Hoek
Current Opinion in Psychiatry Summary & key facts 2020 716 citations

This review found that eating disorders cause a large health and social burden. In 2017 eating disorders accounted for more than 3.3 million healthy years lost worldwide. Anorexia nervosa and bulimia nervosa show rising disability, higher death rates (especially after inpatient treatment for anorexia), lower quality of life, higher costs,…

Eating Disorders and Behaviors Obesity, Physical Activity, Diet Obsessive-Compulsive Spectrum Disorders

Mentalization based treatment for borderline personality disorder

Anthony Bateman, Peter Fonagy
World Psychiatry Summary & key facts 2010 637 citations

Borderline personality disorder (BPD) is a serious mental illness marked by big problems with emotion control, impulsive acts, and unstable self-image and relationships. Many people with BPD hurt themselves or try suicide (recurrent suicidal behaviour in about 69–80% and suicide rates up to 10%). Mentalization-based treatment (MBT) was developed to…

Bipolar Disorder and Treatment Personality Disorders and Psychopathology Psychotherapy Techniques and Applications

Inclusion of people of color in psychedelic-assisted psychotherapy: a review of the literature

Timothy I. Michaels, Jennifer Purdon, Alexis Collins, Monnica T. Williams
BMC Psychiatry Summary & key facts 2018 247 citations

The authors reviewed psychedelic-assisted psychotherapy studies published from 1993 to 2017 to see how many people of color took part. They found 18 studies with about 280 people. About 82% of participants were non-Hispanic White, while only small percentages were African American, Latino, Asian, indigenous, or mixed race. Because so…

Natural Compound Pharmacology Studies Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies Ayahuasca LSD

Meditation and yoga for posttraumatic stress disorder: A meta-analytic review of randomized controlled trials

Autumn M. Gallegos, Hugh F. Crean, Wilfred R. Pigeon, Kathi L. Heffner
Clinical Psychology Review Summary & key facts 2017 178 citations

This paper pooled results from 19 randomized trials with 1,173 adults to see if meditation and yoga change PTSD symptoms. Overall, these mind–body practices were linked to a small-to-medium reduction in PTSD symptoms (effect size = −0.39). The authors found no big differences by type of practice, who was studied,…

Mindfulness and Compassion Interventions Posttraumatic Stress Disorder Research Resilience and Mental Health

MDMA-assisted psychotherapy for treatment of anxiety and other psychological distress related to life-threatening illnesses: a randomized pilot study

Philip E. Wolfson, Julane Andries, Allison A. Feduccia, Lisa Jerome, Julie B. Wang, Emily D. Williams, et al.
Scientific Reports Summary & key facts 2020 161 citations

This small, randomized, double-blind pilot study tested MDMA-assisted psychotherapy for anxiety tied to life‑threatening illness. Eighteen people were enrolled (13 got MDMA, 5 got placebo) and had two blinded 8‑hour therapy sessions, with later open‑label MDMA sessions and 6‑ and 12‑month follow-ups. The MDMA group showed a larger drop in…

Cannabis and Cannabinoid Research Natural Compound Pharmacology Studies Psychedelics and Drug Studies

The Influence of the COVID-19 Pandemic on Social Anxiety: A Systematic Review

Reuben Kindred, Glen Bates

This systematic review looked at 33 studies about social anxiety during the COVID-19 pandemic. The studies suggest social anxiety increased in the general population. Women and people with low incomes appeared more likely to report higher social anxiety. Other links to higher social anxiety included poor coping, weaker social support,…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes COVID-19 and Mental Health Perfectionism, Procrastination, Anxiety Studies

Challenges for providing health care in traumatized populations: barriers for PTSD treatments and the need for new developments

Evaldas Kazlauskas
Global Health Action Summary & key facts 2017 56 citations

Many people worldwide face traumatic events—research estimates about 70% have had at least one in their life. A substantial share of those people, especially in low- and middle-income countries, go on to have posttraumatic stress disorder (PTSD). In recent decades researchers have developed effective, evidence-based PTSD treatments. But many survivors…

Grief, Bereavement, and Mental Health Migration, Health and Trauma Posttraumatic Stress Disorder Research

Rising global burden of anxiety disorders among adolescents and young adults: trends, risk factors, and the impact of socioeconomic disparities and COVID-19 from 1990 to 2021

Fengsai Bie, Xiao-ling YAN, Jie Xing, Leilei Wang, Yang Xu, Guan Wang, et al.
Frontiers in Psychiatry Summary & key facts 2024 41 citations

This study analyzed Global Burden of Disease (GBD) 2021 data from 204 countries to track anxiety disorders in 10–24 year olds from 1990 to 2021. It found a 52% rise in incidence over those 31 years, a sharp increase after 2019, higher rates in females, and rising disability (DALYs) especially…

Bullying, Victimization, and Aggression Child and Adolescent Psychosocial and Emotional Development COVID-19 and Mental Health

Psychedelic Mushrooms in the USA: Knowledge, Patterns of Use, and Association With Health Outcomes

Richard Matzopoulos, Robert Morlock, Amy Morlock, Bernard Lerer, Leonard Lerer
Frontiers in Psychiatry Summary & key facts 2022 41 citations

Researchers ran a national online survey of U.S. adults from November 2020 to March 2021 that was weighted to represent the adult population. They asked about use of psychedelic mushrooms (psilocybin), reasons for use, and mental health. Many users said they took mushrooms for general mental health and well-being. Users…

Biochemical Analysis and Sensing Techniques Chemical synthesis and alkaloids Psychedelics and Drug Studies Psilocybin
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