Frontier mental health research: psychedelics & drug studies

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39 papers

Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic

COVID-19 Mental Disorders Collaborators
PubMed Central (PMC) Summary & key facts 2021 5,135 citations

This study reviewed surveys and used global models to measure how the COVID-19 pandemic changed rates of major depressive disorder and anxiety disorders in 2020. It found that places with higher COVID-19 infection rates and bigger drops in movement had larger increases in these disorders. The authors estimate about 53.2…

COVID-19 and Mental Health Health disparities and outcomes Long-Term Effects of COVID-19

Risks of all-cause and suicide mortality in mental disorders: a meta-review

Edward Chesney, Guy M. Goodwin, Seena Fazel
World Psychiatry Summary & key facts 2014 2,040 citations

This study reviewed systematic reviews to measure death risks in major mental disorders. The authors screened 407 reviews and found 20 that reported mortality risks for 20 different disorders, covering over 1.7 million patients and more than a quarter of a million deaths. Every disorder showed higher all-cause death rates…

Bipolar Disorder and Treatment Mental Health Treatment and Access Suicide and Self-Harm Studies

Epidemiology of anxiety disorders in the 21st century

Borwin Bandelow, Sophie Michaelis
Dialogues in Clinical Neuroscience Summary & key facts 2015 2,024 citations

Anxiety disorders are a group of conditions marked by persistent, excessive fear or worry and behaviors (like avoidance) that cause real trouble in daily life. They are the most common class of psychiatric disorder — large surveys report that up to 33.7% of people will have one in their lifetime…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Mental Health Treatment and Access

Review of the burden of eating disorders: mortality, disability, costs, quality of life, and family burden

Daphne van Hoeken, Hans W. Hoek
Current Opinion in Psychiatry Summary & key facts 2020 716 citations

This review found that eating disorders cause a large health and social burden. In 2017 eating disorders accounted for more than 3.3 million healthy years lost worldwide. Anorexia nervosa and bulimia nervosa show rising disability, higher death rates (especially after inpatient treatment for anorexia), lower quality of life, higher costs,…

Eating Disorders and Behaviors Obesity, Physical Activity, Diet Obsessive-Compulsive Spectrum Disorders

Mentalization based treatment for borderline personality disorder

Anthony Bateman, Peter Fonagy
World Psychiatry Summary & key facts 2010 637 citations

Borderline personality disorder (BPD) is a serious mental illness marked by big problems with emotion control, impulsive acts, and unstable self-image and relationships. Many people with BPD hurt themselves or try suicide (recurrent suicidal behaviour in about 69–80% and suicide rates up to 10%). Mentalization-based treatment (MBT) was developed to…

Bipolar Disorder and Treatment Personality Disorders and Psychopathology Psychotherapy Techniques and Applications

Inclusion of people of color in psychedelic-assisted psychotherapy: a review of the literature

Timothy I. Michaels, Jennifer Purdon, Alexis Collins, Monnica T. Williams
BMC Psychiatry Summary & key facts 2018 247 citations

The authors reviewed psychedelic-assisted psychotherapy studies published from 1993 to 2017 to see how many people of color took part. They found 18 studies with about 280 people. About 82% of participants were non-Hispanic White, while only small percentages were African American, Latino, Asian, indigenous, or mixed race. Because so…

Natural Compound Pharmacology Studies Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies Ayahuasca LSD

The effects of physical activity on cortisol and sleep: A systematic review and meta-analysis

Len De Nys, Kerry Anderson, Esther Frema Ofosu, Gemma C. Ryde, Jenni Connelly, Anna C. Whittaker
Psychoneuroendocrinology Summary & key facts 2022 227 citations

This review combined results from 10 intervention studies to see if physical activity programs change cortisol (a stress hormone) and sleep in adults. The pooled results found lower cortisol after activity programs and some improvement in sleep quality. The authors say the evidence is moderate for cortisol and low for…

Circadian rhythm and melatonin Physical Activity and Health Sleep and related disorders

Mental Health Prevention and Promotion—A Narrative Review

Vijender Singh, Akash Kumar, Snehil Gupta
Frontiers in Psychiatry Summary & key facts 2022 211 citations

This review summarizes research on promoting mental wellbeing and preventing mental illness. It says many prevention and promotion programs work, including newer digital and community-based approaches, but most strong evidence comes from high-income countries. The review notes big gaps in real-world use, especially in low- and middle-income countries, and calls…

Digital Mental Health Interventions Health disparities and outcomes Mental Health Treatment and Access

More treatment but no less depression: The treatment-prevalence paradox

Johan Ormel, Steven D. Hollon, Ronald C. Kessler, Pim Cuijpers, Scott M. Monroe
PubMed Summary & key facts 2022 188 citations

Treatments for depression have gotten better and far more people can get them since the 1980s. Yet the share of people in the general population with depression has not gone down. The authors call this the “treatment-prevalence paradox” and review seven possible explanations. They find little evidence that more cases…

Mental Health Research Topics Mental Health Treatment and Access Treatment of Major Depression

Meditation and yoga for posttraumatic stress disorder: A meta-analytic review of randomized controlled trials

Autumn M. Gallegos, Hugh F. Crean, Wilfred R. Pigeon, Kathi L. Heffner
Clinical Psychology Review Summary & key facts 2017 178 citations

This paper pooled results from 19 randomized trials with 1,173 adults to see if meditation and yoga change PTSD symptoms. Overall, these mind–body practices were linked to a small-to-medium reduction in PTSD symptoms (effect size = −0.39). The authors found no big differences by type of practice, who was studied,…

Mindfulness and Compassion Interventions Posttraumatic Stress Disorder Research Resilience and Mental Health

MDMA-assisted psychotherapy for treatment of anxiety and other psychological distress related to life-threatening illnesses: a randomized pilot study

Philip E. Wolfson, Julane Andries, Allison A. Feduccia, Lisa Jerome, Julie B. Wang, Emily D. Williams, et al.
Scientific Reports Summary & key facts 2020 161 citations

This small, randomized, double-blind pilot study tested MDMA-assisted psychotherapy for anxiety tied to life‑threatening illness. Eighteen people were enrolled (13 got MDMA, 5 got placebo) and had two blinded 8‑hour therapy sessions, with later open‑label MDMA sessions and 6‑ and 12‑month follow-ups. The MDMA group showed a larger drop in…

Cannabis and Cannabinoid Research Natural Compound Pharmacology Studies Psychedelics and Drug Studies

The Influence of the COVID-19 Pandemic on Social Anxiety: A Systematic Review

Reuben Kindred, Glen Bates

This systematic review looked at 33 studies about social anxiety during the COVID-19 pandemic. The studies suggest social anxiety increased in the general population. Women and people with low incomes appeared more likely to report higher social anxiety. Other links to higher social anxiety included poor coping, weaker social support,…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes COVID-19 and Mental Health Perfectionism, Procrastination, Anxiety Studies
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