Frontier mental health research: psychedelics & drug studies

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27 papers

The World Health Organization Adult ADHD Self-Report Scale (ASRS): a short screening scale for use in the general population

Ronald C. Kessler, Lenard A. Adler, Minnie Ames, Olga Demler, Stephen V. Faraone, Eva Hiripi, et al.
PubMed Summary & key facts 2005 3,245 citations

The WHO Adult ADHD Self-Report Scale (ASRS) has 18 questions about recent ADHD symptoms, and a shorter six-question screener was tested against blind clinical diagnoses in 154 people from the US National Comorbidity Survey Replication. Each ASRS item was linked to the clinical rating, but agreement varied a lot across…

Attention Deficit Hyperactivity Disorder Functional Brain Connectivity Studies Neural and Behavioral Psychology Studies

Adult ADHD and comorbid disorders: clinical implications of a dimensional approach

Martin A. Katzman, Timothy S. Bilkey, Pratap Chokka, Angelo Fallu, Larry J. Klassen
BMC Psychiatry Summary & key facts 2017 648 citations

This review says adult ADHD affects about 2.5% of adults and often occurs with other mental health problems. Adults with ADHD commonly have trouble with attention, memory, planning, self-control, and emotions. The condition is often missed or undertreated, is linked with big personal and social problems, and the evidence on…

Attention Deficit Hyperactivity Disorder Functional Brain Connectivity Studies Neural and Behavioral Psychology Studies

Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway

Nora D. Volkow, Gou‐Jen Wang, Jeffrey H. Newcorn, Scott H. Kollins, Timothy Wigal, Frank Telang, et al.
Molecular Psychiatry Summary & key facts 2010 409 citations

Researchers used PET brain scans to compare dopamine reward-system markers in 45 adults with ADHD and 41 adults without ADHD. People with ADHD scored lower on an Achievement scale (a stand-in measure for motivation), and in the ADHD group those lower scores were linked to lower availability of dopamine D2/D3…

Attention Deficit Hyperactivity Disorder Cognitive Abilities and Testing Neural and Behavioral Psychology Studies

Polyvagal Theory: A Science of Safety

Stephen W. Porges

This 2022 paper by Stephen Porges presents Polyvagal Theory as a way to study how feelings of safety come from the body's nervous system. It proposes that safety is not just a mood but has measurable brain–body signals. The paper explains neural pathways (like the ventral vagal complex and a…

Heart Rate Variability and Autonomic Control Neural and Behavioral Psychology Studies Psychosomatic Disorders and Their Treatments

Individual differences in extraversion and dopamine genetics predict neural reward responses

Michael X Cohen, Jennifer Young, Jong Min Baek, Christopher Kessler, Charan Ranganath
Cognitive Brain Research Summary & key facts 2005 271 citations

Researchers ran two fMRI studies using a gambling task to see how personality and a dopamine gene relate to brain reward signals. Rewards were given either right after a response (Study 1) or after a 7.5-second wait (Study 2). The studies found that people’s extraversion scores and whether they carried…

Functional Brain Connectivity Studies Neural and Behavioral Psychology Studies Neurotransmitter Receptor Influence on Behavior

The social brain and reward: social information processing in the human striatum

Jamil P. Bhanji, Mauricio R. Delgado

This 2014 review explains that the brain’s reward system — especially a region called the striatum — responds not only to things like food or money but also to social outcomes such as praise. The authors summarize many studies showing that the striatum carries signals when people evaluate social rewards,…

Neural and Behavioral Psychology Studies Neuroendocrine regulation and behavior Neurotransmitter Receptor Influence on Behavior

Impact of anxiety on prefrontal cortex encoding of cognitive flexibility

Junchol Park, Bita Moghaddam
Neuroscience Summary & key facts 2016 221 citations

This review looks at studies in humans and animals that link anxiety and stress with poorer cognitive flexibility — the ability to change strategies when rules or goals change. It describes evidence that the prefrontal cortex (PFC) is central to flexible behavior, that anxiety or PFC disruptions are associated with…

Memory and Neural Mechanisms Neural and Behavioral Psychology Studies Stress Responses and Cortisol

ADHD and the Prefrontal Cortex

Amy F.T. Arnsten
The Journal of Pediatrics Summary & key facts 2009 198 citations

Research links ADHD — which shows up as inattention, impulsivity, and too much activity — to weaker structure and function in the brain’s prefrontal cortex (PFC), especially on the right side. The PFC helps control top-down attention, stop inappropriate actions, and regulate emotion, and it needs the right balance of…

Attention Deficit Hyperactivity Disorder Functional Brain Connectivity Studies Neural and Behavioral Psychology Studies

Regional Brain Activation during Meditation Shows Time and Practice Effects: An Exploratory FMRI Study

E. Baron Short, Samet Köse, Qiwen Mu, Jeffery J. Borckardt, Andrew B. Newberg, Mark S. George, et al.

Meditation involves attentional regulation and may lead to increased activity in brain regions associated with attention such as dorsal lateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC). Using functional magnetic resonance imaging, we examined whether DLPFC and ACC were activated during meditation. Subjects who meditate were recruited and scanned…

EEG and Brain-Computer Interfaces Mindfulness and Compassion Interventions Neural and Behavioral Psychology Studies

Trait Extraversion and Dopamine Function

Jan Wacker, Luke D. Smillie

Psychological Types is C. G. Jung’s book that grew from about twenty years of his clinical work. It explains his idea that people have different psychological types—most famously introversion and extraversion—and describes four basic functions (thinking, feeling, sensation, intuition). Jung wrote the book to link his clinical observations with wider…

Neural and Behavioral Psychology Studies Neurotransmitter Receptor Influence on Behavior Obsessive-Compulsive Spectrum Disorders

Affective neuroimaging in generalized anxiety disorder: an integrated review

Gregory A. Fonzo, Amit Etkin

This paper reviews task-based fMRI studies of emotion in people with generalized anxiety disorder (GAD). The authors narrowed 608 papers down to 30 studies that measured BOLD (blood oxygenation level–dependent) responses during emotional tasks. Results across studies were mixed: some found increased brain responses, some found decreased responses, and some…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Functional Brain Connectivity Studies Neural and Behavioral Psychology Studies
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