Neurogenetic analysis of childhood disintegrative disorder

Summary & key facts

This document presents an “emerging” 2-item clinician-rated measure from the American Psychiatric Association to record how much social communication problems and restricted interests/repetitive behaviors interfere with a person’s functioning. Each domain is rated by a clinician for the past seven days on a 4-point scale from 0 (None) to 3 (Severe), and the two domain scores are reported separately. The APA says the measure can help with treatment planning and tracking change, but it should not be the only basis for a diagnosis and researchers and clinicians are asked to provide feedback on its usefulness.

Key facts:

• The measure has 2 items: one scores SOCIAL COMMUNICATION and the other scores RESTRICTED INTERESTS and REPETITIVE BEHAVIORS, and each is rated separately.
• Ratings cover the past seven (7) days and use a 4-point scale: Level 0=None; Level 1=Mild (Requiring support); Level 2=Moderate (Requiring SUBSTANTIAL support); Level 3=Severe (Requiring VERY SUBSTANTIAL support).
• A combined overall severity score should NOT be calculated; each domain’s severity level should be reported on its own.
• The APA describes this as an “emerging measure” intended for initial interviews and to monitor treatment progress, not as the sole basis for making a clinical diagnosis.
• Clinicians complete the measure using their clinical judgment and all available information about the individual at the time of assessment.
• Researchers and clinicians may reproduce the material without permission for use with their patients, and the APA requests feedback about the instruments’ usefulness through its DSM-5 feedback form.

Topics

Autism Spectrum Disorder Research Genetics and Neurodevelopmental Disorders Genomic variations and chromosomal abnormalities

Categories

Cognitive Neuroscience Life Sciences Neuroscience

Tags

Autism Autism spectrum disorder Biology Candidate gene Cohort Copy-number variation Developmental psychology Exome sequencing Gene Genetics Genome Internal medicine Medicine Mutation Phenotype Proband Psychology Socioemotional selectivity theory